Manchester United has been drawn against fellow Premier League side Brighton & Hove Albion in the quarter-finals of the FA Cup.
Twelve-time champions United, who beat Huddersfield Town to reach the last eight for a fourth consecutive campaign, are bidding for a second title in the last three seasons.
Brighton, meanwhile, overcame League Two side Coventry City to reach the quarter-finals for the first time in 32 years and are going in search of only a second ever appearance in the final of the competition.
The tie could be one of four all-Premier League contests in the quarter-finals, although the four Champions League-chasing teams to still be involved have all been kept apart.
Premier League champions Chelsea face a quarter-final trip to Leicester City, who last reached the final of the competition in 1969.
Manchester City, meanwhile, will continue their pursuit of a quadruple against top-flight opposition in the form of Southampton if they are able to beat Wigan Athletic in their fifth-round clash on Monday night.
Tottenham Hotspur are also yet to play their fifth-round game, but if they can avoid an upset against Rochdale on Sunday then they will face either Sheffield Wednesday or Swansea City, who were contest a replay at the Liberty Stadium following a 0-0 draw on Saturday.
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FA Cup quarter-final draw in full:
Sheffield or Swansea vs. Rochdale or Tottenham
Man U vs. Brighton
Leicester City vs. Chelsea
Wigan Athletic or Man City vs. Southampton